Regulation of c-myc protooncogene by antisense RNA.
نویسندگان
چکیده
منابع مشابه
Regulation of RNA Polymerase II Elongation by c-Myc
The genome-wide mapping presented in this issue by Rahl et al. (2010) demonstrates how the transcription factor c-Myc interfaces with the machinery that controls RNA polymerase II elongation. These findings account for the ability of c-Myc to activate the expression of a large number of genes that promote rapid proliferation.
متن کاملThe c-MYC Protooncogene Expression in Cholesteatoma
Cholesteatoma is an epidermoid cyst, which is most frequently found in the middle ear. The matrix of cholesteatoma is histologically similar to the matrix of the epidermoid cyst of the skin (atheroma); their epithelium is characterized by hyperproliferation. The c-MYC protooncogene located on chromosome 8q24 encodes a transcription factor involved in the regulation of cell proliferation and dif...
متن کاملInhibition of c-myc expression in cells by targeting an RNA-protein interaction using antisense oligonucleotides.
Antisense oligodeoxynucleotides (ODNs) are designed to bind to and inhibit a target mRNA. We used a novel approach for the design of ODNs to the c-myc mRNA using protein binding sites as targets for ODN action. Our strategy was to identify ODNs that could interfere with the coding region determinant-binding protein (CRD-BP), a protein that binds to the CRD region of the c-myc mRNA. Using an in ...
متن کاملc-myc protooncogene expression in mouse erythroleukemia cells.
Murine erythroleukemia (MEL) cells are erythroid progenitors whose programs of erythroid differentiation has been interrupted by transformation with the Friend virus complex. As a result of the ability of certain chemicals such as dimethylsulfoxide (DMSO) to induce terminal erythroid differentiation, the cells have been used as a model for understanding the molecular basis of cellular different...
متن کاملElectroporation enhances c-myc antisense oligodeoxynucleotide efficacy.
Obtaining high transfection efficiencies and achieving appropriate intracellular concentrations and localization are two of the most important barriers to the implementation of gene targeted therapy. The efficiency of endogenous uptake of oligodeoxynucleotides (ODNs) varies from cell type to cell type and may be a limiting factor of antisense efficacy. The use of electroporation to obtain high ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Drug Delivery System
سال: 1992
ISSN: 1881-2732,0913-5006
DOI: 10.2745/dds.7.417